Scientists have long tried to find the target of cannabinoid action in the human body. This was accomplished in 1988 when the corresponding receptors of type 1 were studies. In 1993, the second class of them was discovered. CB1 receptors are located in the central nervous system. Activation and blocking of CB1 affect memory, neuroprotection, and nociception. In addition to the brain, they can be found in the liver, myocardium, kidneys, gastrointestinal tract, lungs, as well as in the endothelial lining and muscle wall of blood vessels. CB2 is widely represented on immune and endothelial cells. Synthetic cannabinoids, which are contained in smoking mixtures, mainly stimulate CB1 receptors – that is why these drugs seriously change the mental state of a person. That’s why they are still subjects of different researches.
What are cannabinoids? Description & facts
Plant and synthetic cannabinoids are a group of special derivatives. Natural cannabinoid found in plants of the cannabis. Responsible for the psychedelic effect of cannabis is delta-9-tetrahydrocannabinol, which is able to selectively bind to brain CB1 and CB2. At present, there are also synthetic chemicals that have a structure similar to plant samples and have the same pharmacological action.
Synthetic cannabinoid use
The psychotropic effects of synthetic cannabinoid are very similar to the general one in duration: about 3-5 hours.